Bodybuilding Supplements Brands – The Top 50 Most Popular Brands in the USA

Bodybuilding Supplements Brands. Navigating the world of bodybuilding supplements can be as intense as a final heavy set on leg day. With countless brands vying for your attention, how do you separate the proven performers from the marketing hype? This definitive guide cuts through the noise to bring you the 50 most popular bodybuilding supplement brands in the USA. We’ve analyzed market presence, consumer loyalty, and industry reputation to provide you with a curated list that serves as your ultimate resource. For each brand, you’ll find a detailed breakdown of what makes them unique, their flagship products, and the specific type of athlete they serve. Whether you’re a seasoned competitor, a gym newbie, or somewhere in between, use this guide to make informed decisions that support your fitness journey and help you achieve your peak physical potential.

1. Optimum Nutrition (ON)

As a titan in the industry, Optimum Nutrition has earned its “Gold Standard” reputation for a reason. Primarily known for its exceptionally high-quality whey protein powders, ON consistently delivers on purity, mixability, and taste. Their flagship product, Gold Standard 100% Whey, is a bestseller worldwide, undergoing rigorous testing to ensure it meets label claims and is free from unwanted fillers. Beyond protein, their extensive catalog includes pre-workouts like Amino Energy, creatine monohydrate, and BCAA powders, all manufactured in own certified facilities for superior quality control. For athletes seeking reliability, consistent results, and a trusted name that has stood the test of time, Optimum Nutrition remains the undisputed go-to choice for millions.

2. Dymatize

Dymatize is a powerhouse brand recognized for its fast-absorbing and great-tasting protein formulas, making it a favorite among athletes with busy schedules. Their ISO 100 Hydrolyzed Whey Protein is legendary in the fitness community; through advanced hydrolysis, the protein is broken down into smaller peptides for rapid digestion and absorption, making it ideal for post-workout recovery. Dymatize also excels with their pre-workout lineup, including the super-potent PRE WORKOUT, which delivers intense energy and focus. With a strong commitment to science-backed formulations and transparency, Dymatize provides effective supplements for those who refuse to compromise on speed or quality in their nutrition.

3. BSN

BSN revolutionized the supplement industry with its focus on flavor and complex, synergistic formulas. Famous for their incredibly delicious SYNTHA-6 protein powder, which features a multi-phase protein blend that provides both fast and sustained amino acid release, BSN makes meeting your daily protein intake a genuine pleasure. Their pre-workout, N.O.-XPLODE, is an iconic product known for its energy-boosting and pump-inducing effects, helping to ignite training sessions. BSN’s philosophy centers on creating a sensory experience without sacrificing performance, making them the perfect brand for those who prioritize taste and advanced, multi-action supplement solutions.

4. MuscleTech

A true behemoth in the performance supplement space, MuscleTech is renowned for its heavy investment in scientific research and development. They have been behind some of the most innovative and talked-about products in history, such as Nitro-Tech, one of the first whey protein isolates clinically documented to significantly outperform standard whey in muscle building. Their pre-workout, Platinum Series 100% Creatine, and mass gainers like Mass-Tech are staples for hardcore bodybuilders. MuscleTech consistently pushes the envelope, offering cutting-edge formulas for athletes who are driven by data, clinical studies, and maximum results.

5. Cellucor

Cellucor has cemented its place as a leader through high-quality, effective, and great-tasting products that resonate with a broad audience. Their C4 Pre-Workout is one of the best-selling pre-workouts of all time, celebrated for its reliable energy, tingling-free pumps, and wide array of flavorful options. Beyond C4, Cellucor’s COR-Performance Whey protein offers a clean, versatile protein source that mixes effortlessly. The brand embodies a spirit of motivation and community, creating supplements designed to fuel every rep, set, and personal record for athletes at all levels.

6. GAT Sport

With a history dating back to the golden era of bodybuilding, GAT Sport has maintained its status as a trusted, athlete-driven brand. They are known for producing high-potency supplements that deliver tangible results. Their flagship pre-workout, JetFuse NOX, is a powerful, stimulant-packed formula designed for explosive workouts, while their Nitraflex line has gained a cult following for its potent pump and performance-enhancing matrix. GAT focuses on creating products for dedicated lifters who demand intense, feel-the-difference formulas to power through the most demanding training sessions.

7. JYM Supplement Science

Founded by Dr. Jim Stoppani, JYM Supplement Science was created to combat the problem of “proprietary blends” and under-dosed ingredients. The brand is built on a foundation of full transparency, with every product revealing the exact dose of every ingredient. His flagship Pre JYM pre-workout is a meticulously dosed complex of creatine, beta-alanine, betaine, and BCAAs designed to be taken with Post JYM and Pro JYM for a complete, synergistic system. For the educated consumer who wants to know exactly what they are putting in their body and why, JYM offers a science-backed, no-shortcuts approach.

8. Ghost

Ghost has taken the industry by storm with its unparalleled branding, authentic marketing, and unique collaborations. Known for their transparent label policy and “fully disclosed” formulas, Ghost creates high-quality supplements with a cool, lifestyle-oriented edge. Their Legend pre-workout and Whey protein are not only highly effective but also feature iconic flavor partnerships with brands like Nutter Butter, Chips Ahoy!, and Warheads. Ghost resonates with a new generation of fitness enthusiasts who value transparency, great taste, and a brand that aligns with their lifestyle.

9. Transparent Labs

As the name implies, Transparent Labs has built its entire identity on 100% ingredient transparency and the exclusion of artificial sweeteners, colors, and preservatives. Every product provides a fully open label, allowing you to see the exact amount of every active ingredient. Their ProteinSeries 100% Grass-Fed Whey Isolate is sourced from pasture-raised cows and is one of the purest proteins on the market. Their pre-workout, Stim-Based and Stim-Free, are praised for their robust, effective dosing. For the purist who demands clean, honest, and potent supplements, Transparent Labs is a premier choice.

10. Kaged Muscle

Founded by renowned bodybuilder and coach Kris Gethin, Kaged Muscle focuses on creating clean, high-quality supplements with an emphasis on purity and bioavailability. They utilize patented and premium ingredients, such as Micropure Creatine HCl and ProHydrolase enzyme technology in their protein, to enhance absorption and reduce digestive discomfort. Kaged Muscle products are designed for the disciplined athlete who prioritizes the quality of each ingredient and seeks maximum efficiency from their supplement regimen without any unnecessary fillers.

11. RSP Nutrition

RSP Nutrition is dedicated to providing high-quality, affordable supplements without cutting corners. Their philosophy is “Real Science. Real People.” which they back up with transparent labeling and effective formulas. Their TrueFit protein powder is a popular meal replacement that includes protein, greens, healthy fats, and fiber. Their AminoLean energy and BCAA powder is a versatile favorite for fasted training. RSP is a go-to brand for value-conscious consumers who still demand quality, efficacy, and great taste from their supplements.

12. EVLUTION Nutrition

EVLUTION Nutrition focuses on delivering scientifically supported supplements at an exceptional value. Their product line is straightforward, effective, and designed to meet the core needs of any athlete. EVL’s PumpMode pre-workout and BCAA Energy are popular for their reliable performance and budget-friendly price points. Their 100% Whey Protein is a clean and simple protein source that delivers quality without a premium price tag. EVLUTION is the smart choice for athletes who want proven ingredients and solid results without breaking the bank.

13. BPI Sports

BPI Sports is known for its innovative and often “best-tasting” products that deliver on both flavor and function. They gained massive popularity with their Whey-HD protein, which is consistently rated highly for its rich, dessert-like flavors. Their pre-workout, 1MR (1 More Rep), is a potent energy and focus formula with a strong legacy. BPI Sports consistently pushes the envelope with unique products like their PUMP-HD and BCAA-HD, making them a favorite for those who want effective supplements with an extra emphasis on a great taste experience.

14. RedCon1

RedCon1 is a top-tier, military-themed supplement company known for its potent, high-stimulant formulas and aggressive branding. Founded by industry veteran Aaron Singerman, RedCon1 has developed a loyal following for products that deliver intense, feelable effects. Their pre-workout, Total War, is renowned for its powerful energy and focus, while their Grunt protein is a high-quality isolate. RedCon1 caters to hardcore athletes and operators who seek maximum-intensity supplements to fuel their most demanding missions, both in and out of the gym.

15. Animal

Animal embodies the spirit of old-school, hardcore bodybuilding. Known for their iconic “paks,” Animal Pak is the ultimate all-in-one training and nutrition supplement, providing a comprehensive array of vitamins, minerals, antioxidants, and performance aids in one convenient pack. Their Universal brand, under which Animal falls, also produces classic whey protein and creatine. Animal represents a no-frills, gritty approach to bodybuilding, appealing to purists who believe in the fundamentals of training, nutrition, and proven supplement stacks.

16. GNC

As one of the largest specialty retailers of health and wellness products, GNC’s house brands offer incredible value and wide accessibility. Their Pro Performance line provides a full spectrum of basics—from whey protein to creatine and multivitamins—at an affordable price point, making it an excellent entry point for beginners. Their more premium GNC Mega Men and Lean Shake lines are also highly popular. For anyone who wants convenient, cost-effective, and reliable supplements available at thousands of locations nationwide, GNC’s brands are a trustworthy solution.

17. Isopure

Isopure is a pioneer and leader in the low-carb and lactose-free protein category. Their signature product, Isopure Zero Carb, is a 100% whey protein isolate that is incredibly pure, mixes clearly in water, and is perfect for those on ketogenic or low-carb diets. They also offer protein-infused drinks and ready-to-drink options. Isopure is the definitive brand for individuals with specific dietary needs, including those who are lactose intolerant or anyone seeking an ultra-pure protein source without carbohydrates or fat.

18. Myprotein

Myprotein is a UK-based giant that has dominated the US market with its direct-to-consumer model, offering an enormous range of products at highly competitive prices. Their Impact Whey Isolate is one of the best-selling proteins globally due to its vast flavor selection and low cost per serving. Beyond protein, they sell everything from vitamins to clothing. Myprotein is the ultimate destination for budget-conscious buyers who want to stock up on high-quality basics without sacrificing variety or flavor options.

19. Rule 1

Rule 1 lives by a simple philosophy: provide pure, high-quality supplements with minimal, clean ingredients. Their namesake product, R1 Protein, is a straightforward blend of whey isolate and concentrate with no artificial colors or sweeteners, offering exceptional purity and mixability. Their pre-workouts and BCAAs follow the same principle. Rule 1 is the ideal brand for the minimalist who believes in the “rule of ones”—one goal, one focus, and supplements with one purpose: to deliver pure, unadulterated performance and results.

20. MTS Nutrition

MTS Nutrition, founded by professional athlete and coach Marc Lobliner, is built on the pillars of taste, transparency, and effectiveness. The brand is famous for its incredible-tasting products, especially their Machine Whey protein and pre-workout. All MTS products feature fully transparent labels, so users know the exact dosage of every ingredient. MTS caters to serious athletes who refuse to compromise on flavor or formula and want a brand that is as passionate about results as they are.

21. PEScience

PEScience stands out for its scientifically-driven approach and innovative product formulations. They are best known for their Select Protein, a unique blend of whey and casein that provides a fast-absorbing protein hit with a sustained release, making it ideal for any time of day. Their pre-workout, High Volume, is a non-stimulant pump product backed by strong clinical research. PEScience appeals to the intelligent consumer who appreciates clever formulation, scientific validation, and multi-purpose products that deliver enhanced utility and results.

22. Beast Sports Nutrition

With a name that says it all, Beast Sports Nutrition creates products for athletes who are building a beast-like physique. They offer a comprehensive range of supplements, from their popular mass gainer, Super Mass Gainer, to their potent pre-workout, Rampage. Beast Sports has a long history in the industry and is trusted by athletes who need powerful formulas to support intense training, significant calorie demands, and aggressive muscle growth.

23. NutraBio

NutraBio is a leader in the fight for full supplement transparency. They were one of the first brands to use fully open labels, disclosing every single ingredient and its exact dose. Their manufacturing facility is cGMP certified, ensuring pharmaceutical-grade quality. From their Classic Whey Isolate to their extremely potent pre-workouts, every NutraBio product is a testament to their commitment to quality and honesty. They are the top choice for the ultra-informed consumer who will accept nothing less than complete disclosure and superior manufacturing standards.

24. Betancourt Nutrition

With deep roots in the bodybuilding community, Betancourt Nutrition combines old-school principles with modern science. They offer a wide array of products, including their popular Bull Rush pre-workout and high-quality whey proteins. Known for their great flavors and effective formulas, Betancourt maintains a family-owned feel while delivering professional-grade supplements trusted by athletes for decades.

25. Bare Performance Nutrition (BPN)

BPN has built a massive and loyal community through its educational content and high-quality, transparent supplements. Founded by Nick Bare, the brand emphasizes clean ingredients and effective formulas that work. Their BPN Pre-Workout and Creatine Monohydrate are customer favorites for their simplicity and reliability. BPN resonates with a community of athletes who value education, authenticity, and a brand that grows and evolves with them on their fitness journey.

Check also: 20 biggest supplements producers in USA

26. Axe & Sledge

Founded by renowned bodybuilder Seth Feroce, Axe & Sledge embodies a no-excuses, hard work ethic. The brand’s products are designed to be as straightforward and effective as the man behind them. Their The Farm Animal whey protein is known for its great taste and quality, while their pre-workout, The Grind, delivers powerful energy and pumps. Axe & Sledge is for the individual who appreciates directness, potency, and a brand that reflects the grind of bodybuilding.

27. Performix

Performix is known for its innovative, proprietary technologies and sleek, science-backed branding. Their most famous product, SST Pro, utilizes a sustained-release tablet technology designed to deliver ingredients over an extended period. Their ioWhey Protein is a high-quality, low-temperature processed whey. Performix appeals to athletes who are looking for a more sophisticated, technologically advanced approach to their supplement regimen.

28. ANS Performance

ANS Performance (Always Never Satisfied) is known for creating potent, well-dosed, and innovative products. They were one of the first brands to popularize the powerful stimulant DMAA in their pre-workout Dilate, and they continue to create high-performance formulas like Ritual, a stimulant-free pre-workout. ANS is a favorite among experienced users who seek out strong, effective, and often unique ingredient combinations.

29. Metabolic Nutrition

Metabolic Nutrition specializes in creating unique, proprietary protein blends. Their most famous line is P-Plex, which includes proteins like PeptoPro, a hydrolyzed casein that is rapidly absorbed and easy on the stomach. They are a brand for those with specific performance and recovery needs, particularly athletes looking for advanced protein solutions beyond standard whey and casein.

30. Naked Nutrition

Naked Nutrition lives up to its name by offering supplements with minimal, single-ingredient profiles. Their Naked Whey is made with just one ingredient: 100% pure grass-fed whey protein concentrate. They also offer Naked Pea, Naked Rice, and other single-source proteins. This brand is perfect for consumers with allergies, sensitivities, or those who simply want the purest, most unadulterated supplement possible with no additives.

31. Gaspari Nutrition

A legacy brand with a storied history, Gaspari Nutrition has made a strong comeback. Known for their incredibly flavorful and effective products, their Myofusion protein was a game-changer in taste and mixability. Their pre-workout, SuperDrive, continues their tradition of potent formulas. Gaspari represents a blend of classic bodybuilding heritage and modern innovation, trusted by a generation of lifters.

32. Legion Athletics

Founded by author and scientist Mike Matthews, Legion Athletics is built on a foundation of evidence-based formulas and 100% transparency. Every ingredient is fully disclosed and dosed effectively, with no proprietary blends. Their Pulse pre-workout and Whey+ protein are meticulously formulated based on the latest scientific research. Legion is for the skeptic who values science over hype and wants supplements that are as effective as they are honest.

33. Steel Supplements

Steel Supplements is known for its hard-hitting, results-oriented products, particularly in the fat loss and performance categories. Their Shredded Steel fat burner and Vengeance pre-workout have strong followings. The brand markets itself aggressively towards those looking for dramatic physical transformations, catering to bodybuilders and fitness models preparing for competitions or photoshoots.

34. Alpha Lion

Alpha Lion has cultivated a powerful brand identity centered around supreme confidence and top-tier performance. Their SuperHuman Pre-Workout is highly regarded for its balanced yet potent energy and focus, while their SuperHuman Protein is praised for its excellent taste and mixability. Alpha Lion connects with athletes who want to feel dominant in the gym and use supplements that match their elite mindset.

35. Jacked Factory

Jacked Factory offers clean, transparent, and affordable supplements with a focus on natural ingredients and flavors. Their Nitrosurge Pre-Workout is a clean, stimulant-based product with fully disclosed doses, and their Growth Surge is a post-workout recovery blend. Jacked Factory is an excellent choice for health-conscious lifters who want effective formulas without artificial sweeteners, colors, or proprietary blends.

36. Primeval Labs

Primeval Labs focuses on creating simple, effective, and great-tasting supplements without unnecessary ingredients. Their Mega Pre Black Edition is a strong, straightforward pre-workout, and their IsoLite protein is a pure whey isolate. The brand appeals to athletes who believe in a back-to-basics approach, favoring potent formulas with clean profiles over marketing hype.

37. Apollon Nutrition

Apollon Nutrition is renowned for creating some of the most potent and heavily-dosed supplements on the market, often referred to as “bareknuckle” formulas. Their Hooligan pre-workout and Asylum energized amino are known for their intense effects. Apollon caters exclusively to the hardcore segment of the market—experienced users with high stimulant tolerances who seek the absolute strongest products available.

38. Blackstone Labs

While often controversial, Blackstone Labs has a dedicated following for its extremely potent pro-hormone and “hardcore” supplement lines. Their Angel Dust pre-workout is infamous for its strength. It’s crucial to note that this brand is for highly experienced users who fully understand the risks and potent nature of the products, and they should always be used with caution.

39. Metabolic Drive

(Note: This is a Biotest brand product, often used interchangeably). Biotest is a long-standing brand known for its unique, research-driven supplements. They are the creators of Plazma, a highly specific peri-workout carbohydrate and amino acid supplement that has a cult-like following for its ability to enhance recovery and growth when used precisely as directed. Biotest serves a niche audience of disciplined athletes who follow specific, timed-nutrition protocols.

40. Bodybuilding.com Signature Brand

The flagship brand of the world’s largest supplement retailer, Bodybuilding.com’s Signature line offers exceptional quality and value. Their Signature 100% Whey Protein and Pre-Workout are formulated to compete with top brands but at a more accessible price point. It’s a trusted, one-stop shop for high-quality basics backed by the retailer’s extensive product knowledge and customer service.

41. Rich Piana’s 5% Nutrition

Founded by the late, legendary bodybuilder Rich Piana, 5% Nutrition is built on the principle that only 5% of people are willing to do what it takes to be the best. The brand’s products, like All Day You May, are designed for this elite 5%, with around-the-clock fueling and hardcore formulas that reflect Rich’s unique and intense philosophy on bodybuilding and life.

42. ProJYM

As part of Dr. Jim Stoppani’s JYM line, ProJYM is a specifically formulated protein blend that mimics the multi-source protein recommended in his training programs. It contains whey isolate, concentrate, casein, and egg white protein for a timed-release amino acid profile. It’s the perfect protein for followers of Stoppani’s science-based training and nutrition systems.

43. MAN Sports

MAN Sports is a no-nonsense brand focused on creating scientifically validated, high-quality supplements. Their flagship pre-workout, Game Day, is a popular non-stimulant option for pumps, while their Isomino is a pure hydrolyzed whey isolate. MAN Sports appeals to the discerning athlete who values peer-reviewed research and clean, effective ingredient profiles.

44. Prime Nutrition

Prime Nutrition is known for its great-tasting, effective, and transparently labeled products. Their Pro Whey protein and Pre-Workout have developed a strong following for their quality and flavor variety. The brand maintains a strong presence in the online fitness community, offering reliable products that deliver on their promises without gimmicks.

45. Core Nutritionals

Core Nutritionals has built a loyal following with its high-quality, great-tasting, and effectively dosed products. Their Core Fury pre-workout and Core ISO protein are customer favorites for their balanced formulas and delicious flavors. The brand emphasizes community and results, creating supplements that are both reliable and enjoyable to use.

46. G Code

G Code positions itself as a premium, “no-BS” brand focused on purity and potency. Their products often feature simple, powerful ingredient lists without fillers. They cater to athletes who are tired of over-complicated blends and want straightforward, high-impact supplements from a brand that prioritizes performance over everything else.

47. Swole Sports Nutrition

Swole Sports Nutrition offers a range of products designed to help athletes get “swole.” Their Pre-Whey and Creatine are straightforward and effective. The brand uses a direct-to-consumer model to provide quality supplements at a competitive price, making it a solid choice for budget-minded bodybuilders.

48. Virtue Labs

Virtue Labs focuses on creating clean, high-quality supplements that are third-party tested for purity and potency. Their Virtue Pre Workout and Virtue Protein are designed with a focus on using premium ingredients. This brand is for the health-conscious athlete who seeks an extra layer of quality assurance through independent testing.

49. Metabolic

Metabolic is known for its aggressive fat loss and performance supplements. Their Afterburner fat burner and Rampage pre-workout are designed for intense, results-driven athletes. The brand targets individuals looking for powerful thermogenic and energy-boosting formulas to support extreme physical conditioning.

50. Cutler Nutrition

Founded by legendary bodybuilder Jay Cutler, this brand reflects the champion’s proven approach to training and nutrition. Their Total Protein and Pre-Pre Workout are formulated with the insight of a four-time Mr. Olympia, offering reliable and effective supplements for athletes who want to follow the blueprint of a true champion.